Top 10 Hyaluronic Acid Suppliers, Manufacturers, Wholesalers, and Traders in Japan

Founded in 1985 in Yokohama, Nippon Hyaluronate Industries (NHI) is often hailed as the "pioneer of modern HA production" in Japan. What started as a small laboratory focused on microbial fermentation has grown into a global leader, supplying over 30% of the world's pharmaceutical-grade hyaluronic acid. NHI's claim to fame? Their proprietary "BioPure Fermentation" process, which uses non-animal sources (think carefully selected strains of Streptococcus zooepidemicus ) to produce HA with ultra-high purity—often exceeding 99.5%. This level of quality has made them a go-to for luxury skincare brands crafting the best hyaluronic acid serum, as well as pharmaceutical companies developing joint health injections and eye drops.

Beyond their technical prowess, NHI prides itself on sustainability. Their production facilities in Kanagawa Prefecture run on 100% renewable energy, and they've implemented a closed-loop water system that reduces waste by 70%. "We believe purity shouldn't come at the planet's expense," says Yuki Tanaka, NHI's Chief Sustainability Officer. "Our clients—whether they're creating a high-end serum or a daily supplement—want ingredients they can feel good about, and that includes how they're made."

NHI's product range is as diverse as their clientele: from low-molecular-weight HA (perfect for deep skin penetration in serums) to high-molecular-weight variants (ideal for long-lasting hydration in moisturizers). They also offer bulk HA powder for supplements, with certifications including ISO 9001, GMP, and Ecocert. It's no wonder brands like Shiseido and (Shiseido) and global supplement giants trust NHI to deliver consistency, batch after batch.

Nestled in the historic city of Kyoto, Kyoto Bioactive Solutions (KBS) is a family-owned business with a focus on "harmony between tradition and science." Founded in 1992 by Dr. Akira Mori, a botanist with a passion for natural ingredients, KBS has carved a niche in organic and plant-derived hyaluronic acid—though they've since expanded to include microbial fermentation methods, too. What sets KBS apart is their obsession with hyaluronic acid skin benefits, and how to maximize them through innovative formulations.

Take their flagship product, "HylaOrganic," a hyaluronic acid derived from organic soybean fermentation. Unlike many synthetic HA options, HylaOrganic contains trace amounts of amino acids and antioxidants naturally produced during fermentation, which KBS claims enhance HA's ability to soothe and repair skin. "We noticed that HA alone is powerful, but when paired with these co-factors, its benefits multiply—think reduced redness, faster recovery from environmental stress, and a more radiant glow," explains Dr. Mori's daughter, Mei, who now leads product development.

KBS primarily caters to indie skincare brands and wellness companies that prioritize clean, organic ingredients. Their minimum order quantities are lower than larger manufacturers (starting at 5kg for powder, 10L for liquid), making them accessible to small businesses. They're also a favorite among formulators creating the best hyaluronic acid serum for sensitive skin, thanks to their hypoallergenic, non-GMO certifications. With a loyal customer base in Europe and North America, KBS proves that sometimes, smaller suppliers offer the most heart—and innovation.

When it comes to scale and reliability, Osaka Hyaluronic Acid Co., Ltd. (OHAC) is a heavyweight. Established in 1978, this Osaka-based manufacturer is one of Japan's largest producers of bulk hyaluronic acid, churning out over 500 tons annually. Their clients span the globe, from multinational cosmetic corporations to pharmaceutical giants, and even food and beverage companies looking to add HA to functional drinks and snacks.

OHAC's strength lies in their vertical integration: they control every step of the process, from sourcing raw materials to packaging and shipping. This allows them to offer competitive pricing without compromising on quality. "We're not just a supplier—we're a partner," says Takeshi Nakamura, OHAC's Sales Director. "If a client needs a custom molecular weight for a specific product, or a rush order for a seasonal launch, we can deliver because we own the entire supply chain."

While OHAC is best known for bulk HA powder and liquid concentrates, they've recently expanded into finished formulations, including a line of "ready-to-use" HA serums for brands that want to skip the formulation step. Their "QuickGlow" serum base, which contains 1% HA and niacinamide, has become a hit among small skincare brands looking to launch the best hyaluronic acid serum without the R&D hassle. With certifications like ISO 22000 (food safety) and FDA registration, OHAC is a safe bet for businesses that need consistency, scale, and speed.

Tokyo Cosmetic Ingredients (TCI) is the supplier behind some of the most talked-about hyaluronic acid products on social media. Founded in 2005, this Tokyo-based company specializes in "cosmeceutical-grade" HA—ingredients designed to bridge the gap between cosmetics and pharmaceuticals, with proven clinical benefits. Their claim to fame? A patented "Micro-Penetrating HA" that's smaller in molecular size than traditional HA, allowing it to penetrate deeper into the skin's layers for longer-lasting hydration.

"Most HA serums only hydrate the top layer of skin, which is why you might notice dryness returning by midday," explains Dr. Haruko Ito, TCI's Head of Research. "Our Micro-Penetrating HA reaches the dermis, where it can support collagen production and improve skin elasticity over time. It's not just about temporary plumpness—it's about long-term skin health." This focus on results has made TCI a favorite among brands marketing the best hyaluronic acid serum for anti-aging, with clinical studies showing a 35% reduction in fine lines after 8 weeks of use.

TCI also offers a range of HA blends, like their "Hyla + Peptide Complex" (HA paired with copper peptides) and "HylaB5" (HA with panthenol). These pre-made blends save brands time and money on formulation, while still delivering standout benefits. With a sleek showroom in Tokyo's Ginza district, TCI often hosts workshops for formulators, teaching them how to maximize hyaluronic acid skin benefits through ingredient synergy. For brands that want to market science-backed products, TCI is the gold standard.

Up north in Hokkaido, where the air is crisp and the landscapes are pristine, Hokkaido Bioferment Technologies (HBT) is redefining "clean" hyaluronic acid. Founded in 2010, HBT uses cold-climate fermentation—yes, you read that right—to produce HA with unique properties. "The cold temperatures slow down the fermentation process, allowing the bacteria to produce HA with a more uniform molecular structure," explains CEO Kenji Watanabe. "This results in a smoother texture, better stability, and enhanced moisture retention."

HBT's HA is particularly popular in high-end skincare and luxury spas, where texture and sensory experience matter as much as efficacy. Their "SilkHyal" liquid HA has a velvety, non-sticky feel that's perfect for serums and face oils, while their "PowderPlus" HA powder dissolves instantly in water, making it a favorite for sheet masks and ampoules. "We once had a client tell us our HA felt 'like applying liquid silk,'" Watanabe laughs. "That's the Hokkaido difference."

Beyond skincare, HBT also supplies HA to the veterinary industry (yes, pets need hydration too!) and the medical device sector, where their ultra-pure HA is used in wound dressings and surgical lubricants. With a focus on small-batch, artisanal production, HBT may not be the biggest supplier, but for brands that prioritize quality over quantity, they're worth every yen.

Yokohama Hyaluronate Labs (YHL) is a research-driven supplier that's constantly pushing the boundaries of what hyaluronic acid can do. Founded in 2012 by a team of biochemists from Yokohama National University, YHL has filed over 20 patents related to HA modification, including cross-linked HA for longer-lasting effects and HA conjugated with other actives like vitamin C and retinol.

One of their most innovative products is "TimeRelease HA," a cross-linked variant that forms a gel-like matrix on the skin, releasing moisture slowly throughout the day. "Traditional HA is great, but it can break down quickly," says Dr. Ryo Suzuki, YHL's Chief Innovation Officer. "TimeRelease HA stays active for up to 12 hours, so you get all-day hydration without reapplying. It's a game-changer for both skincare and supplements—imagine a pill that releases HA gradually into your system, supporting joint health around the clock."

YHL works closely with startups and academic institutions, offering custom R&D services for brands looking to create truly unique products. Their "Innovation Lab" program pairs clients with a dedicated team of scientists to develop tailor-made HA solutions, from new molecular weights to novel delivery systems. While this level of customization comes with a higher price tag, it's attracted forward-thinking brands eager to stand out in a crowded market. As Suzuki puts it: "Why follow trends when you can create them?"

Nagoya Health Ingredients (NHI) is all about hyaluronic acid from the inside out. While many suppliers focus on skincare, NHI specializes in HA for dietary supplements, with a range of products designed to support joint health, gut health, and even oral hydration. "Most people think of HA as a topical ingredient, but its benefits aren't limited to the skin," says Aiko Yamamoto, NHI's Product Manager. "When taken orally, HA can help lubricate joints, support the gut lining, and even improve dry eyes and mouth. It's a true multi-tasker."

NHI's best-selling product is "HylaJoint," a HA powder blended with glucosamine and chondroitin, marketed as one of the best hyaluronic acid supplements for joint mobility. Clinical trials conducted by NHI showed that participants who took HylaJoint daily for 12 weeks reported a 40% reduction in joint stiffness. They also offer "HylaGut," a HA powder with prebiotics, and "HylaOral," a lozenge-form HA for dry mouth relief.

What makes NHI unique is their focus on bioavailability. Their "MicroEncapsulated HA" uses a special coating to protect the HA from stomach acid, ensuring it's absorbed in the intestines where it can be utilized by the body. This attention to detail has made them a trusted supplier for supplement brands in Japan, the US, and Australia. With certifications like cGMP and NSF, NHI proves that when it comes to internal health, quality HA matters just as much as it does for your skin.

Fukuoka Natural Extracts (FNE) is where hyaluronic acid meets botanical magic. Founded in 1998, this Fukuoka-based supplier specializes in "botanical-infused HA," blending pure hyaluronic acid with extracts like green tea, aloe vera, and rice bran to enhance its benefits. "We believe nature and science work best together," says Masaru Kimura, FNE's Founder. "HA provides the hydration, but botanicals add extra nutrients and antioxidants that make the product more effective—and more enjoyable to use."

One of FNE's most popular blends is "HylaGreen," a HA and green tea extract combination that soothes sensitive skin while delivering hydration. "Green tea is rich in EGCG, an antioxidant that helps protect skin from pollution and UV damage," Kimura explains. "When paired with HA, it's like giving your skin a drink and a shield in one." This focus on synergy has made FNE a favorite among natural skincare brands, many of which use their blends to create the best hyaluronic acid serum with added botanical benefits.

FNE also offers a range of organic HA options, certified by the Japan Organic Standard (JOS), for brands targeting eco-conscious consumers. Their organic HA is sourced from sustainably grown sugar beets and fermented using traditional Japanese koji mold, adding a touch of cultural heritage to their products. With a commitment to transparency, FNE provides full traceability reports for every batch, so clients know exactly where their ingredients come from. For brands that want HA with a story—and a little extra botanical flair—FNE delivers.

Sendai Pharma Solutions (SPS) is the supplier for those who need hyaluronic acid that meets the strictest pharmaceutical standards. Founded in 1980 as a division of Tohoku University Hospital, SPS has decades of experience producing HA for medical applications, from intraocular lenses to dermal fillers and wound care products. Today, they're a leading supplier of pharmaceutical-grade HA to drug companies and medical device manufacturers worldwide.

What sets SPS apart is their rigorous quality control. Their production facilities in Miyagi Prefecture are certified to ISO 13485 (medical device quality management), and every batch of HA undergoes over 50 tests for purity, potency, and safety. "When your product is going into someone's eye or joint, there's no room for error," says Dr. Takashi Sato, SPS's Quality Assurance Director. "Our HA is 99.9% pure, with zero contaminants and consistent molecular weight—because precision saves lives."

While SPS primarily serves the medical industry, they also offer "pharma-grade HA" to high-end skincare brands that want to emphasize clinical efficacy. Their "MedHyal" line, which is identical to the HA used in dermal fillers, is a favorite among luxury anti-aging brands marketing the best hyaluronic acid serum for deep wrinkle correction. With a reputation for reliability and expertise, SPS is the gold standard for anyone who needs HA they can trust with their most critical applications.

Rounding out our list is Hiroshima Hyaluronic Innovations (HHI), a young, dynamic supplier that's shaking up the industry with affordable, high-quality HA. Founded in 2015 by a group of former employees from larger HA manufacturers, HHI set out to make premium HA accessible to small and medium-sized businesses, offering competitive pricing without cutting corners on quality.

HHI's secret? A lean, tech-driven business model. They use AI-powered production monitoring to reduce waste, source raw materials directly from farmers to cut out middlemen, and sell primarily online, keeping overhead costs low. "We believe every brand—whether it's a startup or a multinational—deserves access to great HA," says CEO Ren Tanaka. "Our goal is to make high-quality ingredients the norm, not the exception."

Despite their focus on affordability, HHI doesn't skimp on certifications: their HA is GMP-certified, cruelty-free, and vegan. They offer a range of products, from bulk powder to pre-mixed serums, with minimum order quantities as low as 1kg—perfect for startups testing new formulations. Their "BasicHA" powder, a standard 1.5MDa molecular weight HA, has become a bestseller among indie brands creating their first hyaluronic acid serum, thanks to its consistent quality and budget-friendly price. As Tanaka puts it: "Great HA shouldn't break the bank. We're here to prove that."